ACP Journal Club. Review: vitamin and antioxidant supplements do not prevent adverse cardiovascular events.

نویسنده

  • Christopher M Rembold
چکیده

Review methods MEDLINE, EMBASE/Excerpta Medica, Cochrane Library, Scopus, CINAHL, ClinicalTrials.gov (all to Nov 2012); and reference lists were searched for randomized controlled trials (RCTs). 50 RCTs (n = 294 478, mean age 49 to 82 y), including 45 double-blind, placebo-controlled trials and 5 open-label, controlled trials, met the selection criteria. 30 RCTs were done in primary prevention settings, and 20 in secondary prevention settings. Supplementation and follow-up ranged from 6 months to 12 years. Supplements were administered orally and included vitamins A, B6, B12, C, D, and E; β-carotene; folic acid; and selenium. Of 47 RCTs that reported relevant data, 5 were funded by pharmaceutical companies, and mean score was 4.3 (range 2 to 5) out of 5 on the Jadad scale for methodological quality.

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عنوان ژورنال:
  • Annals of internal medicine

دوره 158 12  شماره 

صفحات  -

تاریخ انتشار 2013